Go to main content

Post-endocytic sorting of opioid receptors

Dagunts, Aleksandra
2026
Get Accessible Copy
Download
Formats
Format
BibTeX
MARCXML
TextMARC
MARC
DublinCore
EndNote
NLM
RefWorks
RIS
Add to Basket
Cite

Files

Abstract

This dissertation is focused on the role of post-endocytic sorting in opioid receptor regulation. Specifically, it describes the development of a chemical biology sensor for tracking lysosomal downregulation of GPCRs, and the application of this sensor to determine the mechanism of mu opioid receptor post-endocytic recycling. The effects of this recycling mechanism on opioid receptor signaling are also explored.

Details

Title
Post-endocytic sorting of opioid receptors
Creator
Dagunts, Aleksandra : Oregon Health and Science University : (0000-0001-9378-8017)
Contributor
Lobingier, Braden : Advisor : (0000-0001-7881-7502) : Oregon Health and Science University
Publisher
Oregon Health and Science University
Date
2026-03-18
Subjects
Keywords
DOI
https://doi.org/10.6083/bpxhc44950
Language
English
Related Resource
Has part: https://doi.org/10.1038/s41589-024-01705-2
Has part: https://doi.org/10.1126/sciadv.adx8715
Related work citations

1. Novy B, Dagunts A, Weishaar T, Holland EE, Adoff H, Hutchinson E, De Maria M, Kampmann M, Tsvetanova NG, Lobingier BT. An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation. Nat Chem Biol. 2025 Mar;21(3):360-370. doi: 10.1038/s41589-024-01705-2. Epub 2024 Sep 2. PMID: 39223388; PMCID: PMC11867885.

2. Aleksandra Dagunts et al., Lysosomal down-regulation of the mu opioid receptor is opposed by the Retromer complex. Sci.Adv.12,eadx8715(2026).DOI:10.1126/sciadv.adx8715

Content Type
Dissertation
Degree Type
Ph.D.
Academic Program
Biomedical Sciences
Department
Department of Chemical Physiology and Biochemistry
School
School of Medicine
Copyright Status
Usage Statement
Record ID
44950
Record Created
2026-03-18
Record Appears in
Organizations > Departments and Divisions > School of Medicine Basic Sciences Departments > Department of Chemical Physiology and Biochemistry
OHSU Works > Student Work > Academic Programs > School of Medicine Programs > Biomedical Sciences
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
Theses and Dissertations
Featured Collections
Dissertations
All Records

Statistics

from
to
Export
Download Full History