Serum albumin in relation to change in muscle mass, muscle strength, and muscle power

Serum albumin, the most abundant protein in human plasma, transports hormones such as aldosterone, thyroid hormones and androgens and decreases during inflammatory states. Cytokines including IL‑6, TNF‑α, and CRP reduce circulating albumin levels, which can fall sharply after major illness or more subtly with chronic low‑grade inflammation. Low serum albumin is linked to higher risks of cardiovascular disease, disability and mortality. Sarcopenia, the age‑related loss of muscle mass and strength, is common in older adults and contributes to frailty, falls and loss of independence. This study explores the relationship between inflammation‑related reductions in serum albumin and the development of sarcopenia, highlighting albumin as a potential biomarker for muscle decline and adverse health outcomes in aging.