Clinical decision support systems (CDSS) are computer programs that respond to user activity. They assist clinicians and other health professionals in making better decisions. These systems are used to improve the overall quality of health care. They have helped reduce the cost, prevent errors, save time, and give better end results. Clinical decision support systems are efficient in delivering medical data, hence promoting patient safety, but function differently because of the different designs, definitions, rules, software algorithms, and models they are based on. There is no easy way to group these decision support systems into one common workflow or process. There is a growing need to develop a standard which compares the effectiveness of the various clinical decision support systems.