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Abstract
Prostate cancer is a major health concern, affecting one in six men and ranking as the second leading cause of cancer death in the United States. Chronic prostate inflammation may contribute to carcinogenesis through oxidative imbalance and elevated chemokine activity. Obesity, a known risk factor for both systemic inflammation and prostate cancer, may also influence prostatic inflammatory status. This cross‑sectional study analyzed 661 Caucasian VA patients in Oregon to evaluate whether obesity is associated with NIH Type IV asymptomatic prostate inflammation. Using univariate analyses and multivariate logistic regression, we assessed the relationship between BMI and prostate inflammation while adjusting for age, PSA levels, family cancer history, digital rectal exam findings, statin use, and prostate volume.