The FDA has received millions of reports of adverse events over the last ten years. A clinician's ability to identify potential drug-drug interactions in routine practice, even when aided by decision support software, is limited. To date, the literature does not report any attempts to use FDA Adverse Event Reporting System (AERS) data in clinical decision support systems. Data availability of data elements for patients and administrative information, drug information, and diagnoses, reactions, and outcomes, varies widely. The research question in this preliminary project is to determine if the data elements found in the FDA adverse event case reports were used and displayed by drug-drug interaction software, would that display be useful to clinicians in making prescribing or other therapeutic decisions?