Colorectal cancer is one of the most pervasive and deadly diseases in the world today. Although heavily studied with a wealth of available scientific data, little research has been directed at uniting the various biological metrics to test for novel genetic signals and markers that may be otherwise overlooked in singular studies. The current thesis addresses this by utilizing a combined, multi-method analysis to examine biological archetypes in colorectal adenomas by evaluating patterns of differential expression, co-expression disruption, protein product interaction, and transcription factor binding across an available selection of cancerous cell lines, patient colorectal adenomas and normal patient mucosa.