In this prospective study of 102 adults with chronic rhinosinusitis undergoing functional endoscopic sinus surgery, 23 patients with self-reported depression and 79 without were followed for 12 ± 2 months. Depressed patients reported worse pre- and postoperative health-related quality of life but achieved postoperative improvements comparable to nondepressed patients. Depression was not an independent predictor of quality-of-life change. In contrast, greater improvement in Lund–Kennedy endoscopy scores was significantly associated with gains in functional, physical, and symptom-related outcomes, indicating that objective surgical improvement drives postoperative quality-of-life benefits.
