Recent national incentives have focused on the expansion of health information technology, including electronic health records (EHRs) as a way to address costs, improve quality, reduce medical errors, and ameliorate other dysfunctional aspects of the United States healthcare delivery system. However, the design, implementation, and use of EHRs are complex. Some EHRs may incorporate features that are intended to improve patient safety but may not do so. In other instances, EHRs may introduce new errors or types of errors that detract from patient safety. Thus, it would be beneficial for organizations and clinicians to become aware of evidence-based practices for improving existing EHRs and enhancing overall safety for patients At the core of this project is a systematic review of the literature, which is intended to identify evidence on facets of existing EHRs that can influence patient safety.