Health-related quality of life (HRQOL) in Arab Female Breast Cancer Patients (AFBCPs) in Saudi Arabia can be influenced by multiple factors, such as spirituality, religiosity, social support, age and developmental stage, and the stigma associated with breast cancer. Understanding the role of these factors can raise awareness and help create policies to improve care for breast cancer patients. Yet, there is limited research addressing the impact of these factors on HRQOL in AFBCPs. The purpose of this study was to investigate factors influencing HRQOL in AFBCPs in Saudi Arabia.