Purpose: Discrimination and disparity including increased rates of poverty, homelessness, and lack of access to healthcare, are well-documented in the transgender community. Despite high prevalence of low socioeconomic status (SES), limited health research focuses on this subset of the trans patient population. This study seeks to explore barriers and facilitators to care specific to low SES and homeless trans patients. Conclusion: These interviews elucidate the unique clinical experiences of homeless and low SES transgender patients and offer insight for systems-level process modifications that could improve patient experience of healthcare and care coordination.