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Abstract

Bacillus subtilis Spx is a global transcriptional regulator that is conserved among gram-positive bacteria, in which Spx is required for preventing oxidatively induced proteotoxicity. Upon stress induction, Spx engages RNA polymerase (RNAP) at least partially through interaction with the C-terminal domain of the rpoA- encoded RNAP α subunit (αCTD).

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