Healthcare professionals aim to provide the best care possible, but in the worst situations, the healthcare provided sometimes causes harm to patients. In 1999, the Institute of Medicine published a landmark report titled, “To Err is Human” which claims that between 44,000 and 98,000 people die and more than a million are injured annually from preventable medical errors. One of the many recommendations from the report is to implement healthcare information systems (HIS) to ensure safety. This project consists of a literature review on safety and errors in healthcare information systems.