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Abstract
Hematopoiesis, the life-long process of blood cell production, is maintained through the coordinated division and differentiation of specialized, pluripotent hematopoietic stem cells (HSC). For most of life, HSC reside in bone marrow, where they are maintained in ‘niches’ by the cells of the hematopoietic microenvironment. These niches are thought to help maintain the HSC pool by tightly regulating stem cell quiescence and supporting self-renewal. The overall purpose of this research is to understand the mechanisms of endothelial-dependent HSC regeneration.