Head and neck squamous cell carcinoma (HNSCC) is known to have a high progression rate in certain subpopulations, despite existing treatment methods. Due to the lack of significant symptoms, many patients are diagnosed at later stages (III-IV TNM), which provides a limited timeframe for therapeutic decision-making and treatment. The heterogeneity of behavioral risk factors associated with HNSCC, such as smoking and alcohol consumption, along with tumors arising in various anatomical locations, makes reliable stratification of this cancer extremely challenging. Given the complex nature of this cancer in subpopulations that exhibit rapid progression, the aim is to control progression and administer therapy over the longest possible duration in the least invasive manner. To achieve this objective, we focus on identifying targets related to the mechanisms of high progression rates in HNSCC subpopulations by extracting measured gene signatures and driver genes involved in a range of gene regulation patterns.