The marine environment is a rich source for chemical and biological diversity. Many marine animals are closely associated with symbiotic bacteria. Marine animals have been shown to contain natural products with complex structure and interesting pharmacological activities. These compounds are usually produced within the animal to perform a certain function relevant to the holobiont. These natural products are often synthesized by the bacteria using dedicated biosynthetic enzymes. Thus, genome analysis of microbes can predict the potential for the production of natural products.