PKU requires lifelong management, but the childhood PKU diet does not accommodate for post-adolescent patient variations, including: (1) the diet's effect on blood phenylalanine (Phe) concentrations, and (2) the therapeutic benefits of prescribed blood Phe targets. Most adult patients discontinue the inflexible diet, and are exposed to PKU's adverse effects. Research supports large neutral amino acids (LNAAs) as potential alternative strategy; we propose an additive LNAA strategy. We aim to evaluate the clinical efficacy of a combined treatment strategy: usual care (the PKU diet) with LNAA supplementation.
Details
Title
Large neutral amino acid supplementation improves clinical efficacy of usual care in adult PKU
Creator
Prince, Annie : Oregon Health and Science University Depenweiller, Maria : Oregon Health and Science University Chambers, Ash : Oregon Health and Science University Ahring, Kirsten : Oregon Health and Science University Moseley, Kathryn : Oregon Health and Science University Kumru, Burcu : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2020