It is estimated that more than 50% of smokers who become pregnant will continue to smoke despite the Surgeon General's warning. In some studies, prenatal smoke exposure has been associated with decreased cognitive, motor, and behavioral function in the offspring. We conducted the current analysis to determine whether the neurodevelopmental scores collected by domain on the Ages and Stages Questionnaire (ASQ) scores at 12 months of age differed between offspring of prospectively identified pregnant smokers versus nonsmokers.