Discovering drug targets and virulence factors by mapping the lipid metabolism of the pathogenic fungus histoplasma capsulatum

Nakayasu, Ernesto; Zamith-Miranda, D.; Heyman, H.M.; Burnet, M.C.; Couvillion, S.P.; Zheng, X.; Munoz, N.; Kyle, J.E.; Zink, E.M.; Weitz, K.K.; Bloodsworth, K.J.; Clair, G.; Zucker, J.D.; Teuton, J.R.; Payne, S.H.; Kim, Y.M.; Gil, M. Reyes; Baker, E.S.; Bredeweg, E.L.; Nosanchuk, J.D.

doi:10.6083/vh53ww31p

2020

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Abstract

Lipids are major components of biological membrane, energy storage molecules and cell signaling transducers. Therefore, not surprisingly, lipids play major function in host-pathogen interactions and are frequently targeted for drug development. Seeking to better understand the function of lipids in fungal pathogenesis and identify potential drug targets, we performed a comprehensive analysis of the Histoplasma capsulatum lipid metabolic pathway by integrating proteomic and lipidomic analyses. This analysis resulted in mapping of 5 major lipid metabolic pathways, 19 lipid subclasses and 371 individual lipid species.

Details

Title

Discovering drug targets and virulence factors by mapping the lipid metabolism of the pathogenic fungus histoplasma capsulatum

Creator

Nakayasu, Ernesto : Pacific Northwest National Laboratory
Zamith-Miranda, D. : Pacific Northwest National Laboratory
Heyman, H.M. : Pacific Northwest National Laboratory
Burnet, M.C. : Pacific Northwest National Laboratory
Couvillion, S.P. : Pacific Northwest National Laboratory
Zheng, X. : Pacific Northwest National Laboratory
Munoz, N. : Pacific Northwest National Laboratory
Kyle, J.E. : Pacific Northwest National Laboratory
Zink, E.M. : Pacific Northwest National Laboratory
Weitz, K.K. : Pacific Northwest National Laboratory
Bloodsworth, K.J. : Pacific Northwest National Laboratory
Clair, G. : Pacific Northwest National Laboratory
Zucker, J.D. : Pacific Northwest National Laboratory
Teuton, J.R. : Pacific Northwest National Laboratory
Payne, S.H. : Pacific Northwest National Laboratory
Kim, Y.M. : Pacific Northwest National Laboratory
Gil, M. Reyes : Pacific Northwest National Laboratory
Baker, E.S. : Pacific Northwest National Laboratory
Bredeweg, E.L. : Pacific Northwest National Laboratory
Nosanchuk, J.D. : Pacific Northwest National Laboratory

Meeting Name

Research Week, Oregon Health and Science University, 2020

Publisher

Oregon Health and Science University

Date

2020

Subjects

Lipids
Lipid Bilayers
Multiomics
Virulence Factors

Keywords

lipid metabolic pathways; lipid metabolic map; drug target; fungal infection; histoplasma capsulatum; fungal pathogenesis

DOI

https://doi.org/10.6083/vh53ww31p