Lipids are major components of biological membrane, energy storage molecules and cell signaling transducers. Therefore, not surprisingly, lipids play major function in host-pathogen interactions and are frequently targeted for drug development. Seeking to better understand the function of lipids in fungal pathogenesis and identify potential drug targets, we performed a comprehensive analysis of the Histoplasma capsulatum lipid metabolic pathway by integrating proteomic and lipidomic analyses. This analysis resulted in mapping of 5 major lipid metabolic pathways, 19 lipid subclasses and 371 individual lipid species.
Details
Title
Discovering drug targets and virulence factors by mapping the lipid metabolism of the pathogenic fungus histoplasma capsulatum
Creator
Nakayasu, Ernesto : Pacific Northwest National Laboratory Zamith-Miranda, D. : Pacific Northwest National Laboratory Heyman, H.M. : Pacific Northwest National Laboratory Burnet, M.C. : Pacific Northwest National Laboratory Couvillion, S.P. : Pacific Northwest National Laboratory Zheng, X. : Pacific Northwest National Laboratory Munoz, N. : Pacific Northwest National Laboratory Kyle, J.E. : Pacific Northwest National Laboratory Zink, E.M. : Pacific Northwest National Laboratory Weitz, K.K. : Pacific Northwest National Laboratory Bloodsworth, K.J. : Pacific Northwest National Laboratory Clair, G. : Pacific Northwest National Laboratory Zucker, J.D. : Pacific Northwest National Laboratory Teuton, J.R. : Pacific Northwest National Laboratory Payne, S.H. : Pacific Northwest National Laboratory Kim, Y.M. : Pacific Northwest National Laboratory Gil, M. Reyes : Pacific Northwest National Laboratory Baker, E.S. : Pacific Northwest National Laboratory Bredeweg, E.L. : Pacific Northwest National Laboratory Nosanchuk, J.D. : Pacific Northwest National Laboratory
Meeting Name
Research Week, Oregon Health and Science University, 2020
