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Abstract
Amid spreading legalization of cannabis nationwide, the use of the drug for medicinal or recreation purpose alike is becoming increasingly commonplace. From customized cultivation practices to pharmaceutical developments, cannabis has changed from an illicit substance to a drug used for purposes of both therapy and indulgence. More data are becoming available pertaining to drug pharmacodynamics and pharmacokinetics, which may help guide clinical practices, and better define intoxication, toxicity, and safety profiles. The purpose of this conceptual framework is to briefly explore the pharmacology, demographics, and systematically-weighted evidenced-based therapeutic and adverse effects of cannabis (using the Scottish Intercollegiate Guidelines); highlight clinical, individual, and public implications related to cannabis use, dependence, and abuse; and identify gaps in the literature that could influence research in the future.