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Abstract

Given its central role in low-density lipoprotein (LDL) metabolism, there is interest in exploring proprotein convertase subtisilin/kexin type 9 (PCSK9) as a potential circulating biomarker of atherosclerotic cardiovascular disease (ASCVD) risk. Computed tomography for coronary artery calcium (CAC) scoring provides an accurate assessment of subclinical coronary atherosclerotic plaque burden and can be used to refine cardiovascular risk estimates in individuals without symptoms of ASCVD. In this study, we assessed the correlation of cross-sectional measurements of plasma PCSK9 concentration and CAC score in individuals free of clinical ASCVD.

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