We have previously reported that short-term treatment with the water extract of Centella asiatica (CAW) activates the endogenous antioxidant response pathway and ameliorates cognitive deficits without altering plaque burden in mouse models of β-amyloid (Aβ). Here we investigate whether prolonged CAW exposure in 5xFAD mice has similar effects on cognitive function and Aβ pathology, in addition to markers of antioxidant response and synaptic plasticity. We also used primary neurons isolated from 5xFAD mice to explore how the antioxidant response pathway contributes to these effects.
Details
Title
Long-term Centella asiatica treatment improves cognition, increases synaptic and antioxidant markers and reduces plaque burden in β-amyloid overexpressing mice
Creator
Brandes, Mikah : Oregon Health and Science University Zweig, Jonathan A. : Oregon Health and Science University Tang, Anita : Oregon Health and Science University Caruso, Maya : Oregon Health and Science University Wright, Kirsten M. : Oregon Health and Science University Soumyanath, Amala : Oregon Health and Science University Quinn, Joseph F. : Oregon Health and Science University Gray, Nora E. : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2020
