Premature loss of primary mandibular molars can lead to space loss and subsequent malocclusion, although significant individual variation exists. This study investigates whether mandibular plane angle is associated with the propensity to maintain or lose space following early molar loss. Using pretreatment study casts and cephalometric radiographs from orthodontic patients, space changes in the mandibular arch were evaluated and compared with facial growth pattern. Understanding the relationship between mandibular growth direction and space stability may improve prediction of space loss and guide clinical decisions regarding space maintenance in pediatric patients.