Despite guidelines set by OSHA and CDC as well as literature showing the benefits of high standard precautions (SP) compliance, adherence with SP remains low (Gammon & Gould, 2005; Harris et al, 2017; Reddy et al., 2009). This paper evaluates current literature relating to the barriers associated with poor SP compliance with among health care workers (HCW), as well as a couple current strategies implemented to improve compliance rates.