Radiation therapy is commonly employed in cancer treatment regimens in concert with other treatments but is rarely effective as a monotherapy. Radiation can be enhanced by the application of small molecule checkpoint inhibitors. These drugs are hydrophobic, necessitating a drug delivery agent, such as a polymer. This approach has been applied to breast and ovarian cancer, but has not yet been explored in colorectal.
Details
Title
Novel poly (2-oxazoline) micelle formulation of PARP/PI3K induces immunogenic cell death, enhancing response to triple combination therapy
Creator
Landry, Madeleine : Oregon Health and Science University DuRoss, Allison N. : Oregon Health and Science University Neufeld, Megan J. : Oregon Health and Science University Hahn, Lukas : Oregon Health and Science University Sahay, Gaurav : Oregon Health and Science University Luxenhofer, Robert : Oregon Health and Science University Sun, Conroy : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2020
