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Abstract
Tauopathy and a-synucleinopathy often occur together in human brain diseases but most commonly in the context of B-amyloidosis. Tauopathy induced by a-synucleinopathy in the absence of B-amyloid has been demonstrated in vitro and in cultured cells but compelling examples of this in human disease are rare and limited largely to instances of familial Parkinson's disease due to mutations in the a-synuclein gene.