While multiple hormonal treatment strategies are effective in decreasing both acute and chronic heavy menstrual bleeding (HMB) in adolescents, there are few comparative studies that evaluate hormone dosages. Because estrogen-dependent endometrial repair mechanisms occur through gene signaling pathways, as opposed to direct endometrial effect, we hypothesized that the time until resolution of acute HMB in teens is independent of ethinylestradiol (EE) dose.