The electronic health record (EHR) is now an integral part of the majority of primary care practices, particularly after the passage of the Health Information Technology for Economic and Clinical Health (HITECH) Act. Many studies have been published looking at use of the EHR concerning quality of care, safety, and cost. Many studies have focused on the challenges surrounding EHR implementations. A key factor in the successful practice of primary care, particularly evident in experienced EHR users, is the impact of the EHR on the workflow. This study will provide a systematic review of recent literature examining the impact of the EHR on the workflow of primary care practitioners who are at least six months beyond the initiation of EHR implementation.