Computerized provider order entry (CPOE) is an integral part of a successful clinical information system. In CPOE, clinical users directly enter medications, laboratory, and radiology orders into the computer. Two primary research questions guide this study: 1) How do physicians perceive the usefulness and ease of use of the different order set types? 2) What are the factors associated with physicians’ perceived satisfaction and use of the different order set types? Measuring factors relating to physicians’ perception and satisfaction with order set use will be beneficial for future CPOE system design, development, implementation, and training. This information may have implications for how CPOE order sets can be effectively designed and “marketed” for physician acceptance and use.