Each year in the USA, 35,900 cancers are caused by the human papillomavirus (HPV). These cancers are preventable with the successful completion of the 2-dose HPV vaccination series at 11-12 years of age. There is an association with a strong and consistent provider recommendation and an increase in HPV vaccination rates. A brief education on high-quality HPV vaccine recommendation improves quality of clinical staff?s recommendations while increasing refusals. Future quality improvement project may consider interventions other than education.