Obese asthmatic patients often have severe symptoms and poor responses to treatment. The molecular mechanisms of obesity-related asthma and associated airway hyperreactivity remain unclear, limiting our ability to develop new therapeutic strategies. In humans, increased airway innervation contributes to the pathogenesis of airway hyperreactivity. Here we tested if diet-induced obese mice have nerve-mediated airway hyperreactivity and increased airway sensory nerve innervation.
Details
Title
Airway sensory nerve hyperinnervation in obese mice with airway hyperreactivity
Creator
Calco, Gina N. : Oregon Health and Science University Jacoby, David : Oregon Health and Science University Fryer, Allison : Oregon Health and Science University Nie, Zhenying : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2021