Sex differences in disease susceptibility, including infection, cancer, and autoimmunity, have been well-characterized, with males generally being more susceptible to infections and malignancies, and females more susceptible to autoimmune diseases. While many factors underlie such differences, sex differences in T lymphocytes differentiation and function likely lead to disparate adaptive immune responses and disease control. Indeed, sex hormones, including androgens, are strong regulators of gene expression, and have been implicated as drivers of immunity and regulators of T cell differentiation. Therefore, it is clear that androgens play a role in the regulation of T cell function and differentiation, but the mechanisms of such control remain unknown, including whether such regulation is cell-intrinsic.