The oral microbiome engages in a diverse array of highly sophisticated ecological interactions that are crucial for maintaining symbiosis with the host. Streptococci and corynebacteria are among the most abundant oral commensals and their interactions are critical for normal biofilm development. We have previously revealed a specifically symbiotic interaction between Streptococcus sanguinis and Corynebacterium durum via the release of C. durum fatty acids associated with membrane vesicles (MVs), enhancing bacterial fitness. Overall, our findings have supported the emerging role of commensal Corynebacterium spp. as major drivers of oral biofilm ecology, potentially shaping symbiotic health-associated biofilm communities.