Nontuberculous mycobacteria (NTM) is a pulmonary infection that can cause chronic, debilitating disease, primarily affecting the elderly and women. The Coronavirus Disease 2019 (COVID-19) poses disproportionate danger to this subset population with increased risk of long-term complications, hospitalizations, and even death. There are currently scant data reporting the experience of people with chronic respiratory diseases, such as NTM, in the pandemic era. The objective of this study is to describe baseline characteristics, knowledge, and behavior changes in patients with NTM disease in the setting of the COVID-19 pandemic.