The prevention of bleeding and protection of the vascular wall integrity is mediated by the blood cells platelets and enzymatic coagulation reactions in a process called hemostasis. An imbalance in this intricate hemostatic interplay of platelets and coagulation enzymes will cause pathological thrombus formation and this may lead to cardiovascular diseases such as myocardial infarction, stroke, and venous thrombosis. The present research focuses on the role of platelets in providing a surface that support coagulation and function and how platelets activation states can be affected by interference of their signaling cascades by environmental and dietary components.