Our multidisciplinary central nervous system (CNS) clinic provides synchronous consultation and follow-up visits with a neurosurgeon and a radiation oncologist at a community hospital center. Hypofractionated stereotactic radiosurgery (hfSRS) is commonly used for management of primary and secondary malignant disease of the brain. A significant challenge in the follow-up of patients treated with hfSRS to brain lesions is to distinguish pseudoprogression (PP) from tumor recurrence (TR) for which treatment and prognosis are different. The aim of this review was to determine the rate of tumor control (TC), pseudoprogression (PP) and tumor recurrence (TR) among adult patients with brain primary and secondary malignant disease treated at a multidisciplinary CNS community hospital center clinic with hfSRS.