Early transfusion with mesenchymal stem cell derived extracellular vesicles: a new transfusion strategy for life-threatening hemorrhage and traumatic brain injury
Life-threatening hemorrhage and traumatic brain injury (TBI) have a significantly increasing global burden and remain leading causes of preventable deaths. Effective interventions may protect the brain against ongoing damage and improve the long-term outcomes. A growing area of interest is transfusion of cell-based therapies, particularly with bone marrow-derived mesenchymal stem cells (MSC). Transfusion using MSC derived extracellular vesicles (EVs) have shown to improve neurologic outcomes in animal models of life-threatening hemorrhage, stroke, and TBI. However, the precise mechanisms remain poorly characterized. In the present study, we aimed to elucidate some of the key cerebral genes, pathways, and networks that were modulated after transfusion of EVs in a porcine model of hemorrhagic shock (HS) and TBI.
Details
Title
Early transfusion with mesenchymal stem cell derived extracellular vesicles: a new transfusion strategy for life-threatening hemorrhage and traumatic brain injury
Creator
Dekker, Simone : Oregon Health and Science University Bambakidis, Ted : Oregon Health and Science University Williams, Aaron M. : Oregon Health and Science University Biesterveld, Ben : Oregon Health and Science University Bhatti, Umar : Oregon Health and Science University Li, Yongqing : Oregon Health and Science University Pickell, Zachary : Oregon Health and Science University Buller, Benjamin : Oregon Health and Science University Alam, Hasan B. : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2022