Associations between GABRA2 genetic variation, subjective response to acute alcohol intoxication, and the functional connectivity of the reward circuitry
The GABRA2 gene encodes a subunit of a GABAA receptor found in the mesolimbic reward circuitry, and modulation of GABAA receptors by alcohol is hypothesized to contribute to the psychotropic properties of the drug. Linkage studies have found a significant correlation between a single nucleotide polymorphism (SNP, rs279858) in the GABRA2 gene and increased risk for alcohol use disorders (AUDs).
Details
Title
Associations between GABRA2 genetic variation, subjective response to acute alcohol intoxication, and the functional connectivity of the reward circuitry
Creator
Hart, Elijah R. : Oregon Health and Science University Gilbert, Sydney J. : Oregon Health and Science University Boyd, Stephen J. : Oregon Health and Science University Morales, Angelica M. : Oregon Health and Science University Mitchell, Suzanne H. : Oregon Health and Science University Nagel, Bonnie J. : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2022