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Abstract
Cytomegalovirus (CMV) infection has been linked to age-related conditions, yet demographic and medical factors associated with CMV seropositivity in older men remain unclear. This cross-sectional analysis of 1,586 men aged ≥65 years from the Osteoporotic Fractures in Men (MrOS) cohort evaluated associations between CMV serostatus and demographic, socioeconomic, and health characteristics. Overall, 73% were CMV seropositive, with prevalence increasing from 68.9% (age 65–69) to 81.8% (>80 years). Seroprevalence varied by clinic site and was higher among non-white men (PR=1.24) and those with children (PR=1.15–1.17). Higher education was inversely associated with CMV positivity (college graduates PR=0.85; p=0.003). Age and clinic site remained significant predictors in multivariable models. These findings highlight subgroups of older men at increased risk for CMV infection and inform future research on CMV as a potential contributor to functional decline and chronic disease in aging populations.