Amyloid beta (A?) plaques represent one of the classic hallmarks of Alzheimer's disease (AD) pathology in the brain. In rhesus macaques, these plaques start becoming prominent when the animals are 20+ years old, although the underlying cause(s) are unclear. In the present study, our goal was to test the hypothesis that exposure to a Western-style, high-fat, high-sugar diet (WSD) and/or loss of ovarian steroids would advance the development of this histological marker of AD pathology.
Details
Title
Effect of hormone replacement therapy on amyloid beta expression in the amygdala of aged Rhesus Macaques
Creator
Appleman, Maria-Luisa : Oregon Health and Science University Nilaver, Benjamin : Oregon Health and Science University Kohama, Steven G. : Oregon Health and Science University Urbanski, Henryk F. : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2022
