Files
Abstract
Positive margins occur in ~30% of lumpectomies, often requiring reoperation. This study aimed to improve surgical outcomes using an optical wire for light-guided lumpectomy and a novel method to estimate lesion distance intraoperatively. An optical wire combining a fiber and localization wire produced a visible glow around the lesion, aiding excision. In a pilot study of eight patients, seven achieved negative margins. To quantify distance, frequency-domain phase lag measurements were tested in tissue phantoms and mastectomy specimens, showing linear correlation with distance and <15% error. These findings support light-guided lumpectomy with phase-based distance estimation as a promising approach.