Weight loss as a predictor of resolution of symptoms in subjects with idiopathic intracranial hypertension

Idiopathic intracranial hypertension (IIH) is characterized by elevated cerebrospinal fluid pressure without an identifiable cause, commonly affecting overweight women of childbearing age. Diagnosis follows the Modified Dandy Criteria, and management typically begins with weight loss and carbonic anhydrase inhibitors; surgical options are considered for refractory cases. Given the link between obesity and IIH, this study evaluated whether absolute weight loss, percent weight loss, or BMI change predict symptom improvement. Logistic regression revealed weight loss significantly increased the likelihood of improvement in headache, vision, and tinnitus. These findings support weight reduction as a key therapeutic recommendation for IIH patients.