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α2δ proteins (CACNA2D1-4) are auxiliary subunits to voltage-gated calcium channels (VGCCs), and they contribute to VGCC trafficking to the plasma membrane. However, the [...]
2021 |
Dissertation |
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By leveraging the inhibitory effects of divalent cations Ca2+ and Ba2+, I determined the structure of a homotrimeric ASIC in a high pH resting conformation by both x-ray [...]
2019 |
Dissertation |
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Aldosterone acts via the mineralocorticoid receptor to regulate transcription of genes encoding aldosterone-induced proteins. This dissertation sought to identify these p [...]
2019 |
Dissertation |
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Angiotensin converting enzyme 2 (ACE2) is a key regulator of the renin angiotensin system (RAS) that acts by degrading angiotensin II (AngII). Within the kidney, ACE2 is [...]
2024-02-14 |
Dissertation |
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The epithelial sodium channel (ENaC) is expressed at the apical side of epithelial cells and is a key regulator of salt and water balance. By serving as the rate-limiting [...]
2020 |
Dissertation |
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