Acute myeloid leukemia (AML) is a malignancy with a poor survival rate, primarily due to resistance to chemotherapy.Combination therapy using gilteritinib with venetocla [...]

MYC is an enigmatic master regulator implicated in nearly every facet of cellular biology. Throughout my PhD research and deep engagement with the literature, my singular [...]

Androgen hormones regulate the activity of myriad cells of the immune system and are strong drivers of sex differences in disease susceptibility, yet little is known of t [...]

The majority of PDGFRA-mutant gastrointestinal stromal tumors (GIST) harbor exon 18 mutations, most commonly D842V, which is treated with avapritinib (a new type I TKI) b [...]

This dissertation investigates the role of weaning-induced liver tissue remodeling, known as involution, on stromal cells in the liver. We transcriptionally investigate c [...]

This thesis investigates Acute Myeloid Leukemia, focusing on the PEAR1 gene and receptor, analyzed using the IL-3 withdrawal assay and other techniques. All bench work [...]

2025-03-19 | Thesis |

A dissertation discussing the role of mesenchymal kit ligand (kitl) in the pancreas, specifically in regards to healthy tissue homeostasis, tissue architecture, and disea [...]

This thesis describes the role of RI-I modulation in the vascular system. I identify a novel role for RIG-I activation in endothelial function, as well as a role for RIG- [...]

Immune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. I [...]

Genetic heterogeneity makes clinical interventions challenging for patients with acute myeloid leukemia (AML). Identifying and targeting common microenvironment-driven pa [...]