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The mutational status of platelet-receptor PEAR1 was recently identified as a major factor for survival of young patients with Acute Myeloid Leukemia. While studies show [...]

Early phase oncology trials often require a continuous safety monitoring because of the unexpected toxicity associated with investigational agents. Safety monitoring beco [...]

Acute Myeloid Leukemia (AML) is an aggressive cancer with poor overall survival due to frequent relapse. FMS-like tyrosine kinase (FLT3) is the most commonly mutated gene [...]

Individuals who inherit a pathogenic mutation in SDHA have an increased risk of cancer. However, there is often insufficient evidence to properly assess pathogenicity, an [...]

This thesis investigates Acute Myeloid Leukemia, focusing on the PEAR1 gene and receptor, analyzed using the IL-3 withdrawal assay and other techniques. All bench work [...]

2025-03-19 | Thesis |

Leukemias comprise a family of hematologic malignancies characterized by the over-proliferation of myeloid precursor cells. Leukemia development depends on multiple facto [...]

Acute myeloid leukemia (AML) is the most common leukemia in adults and is primarily diagnosed in older patients. The combination of the BCL2 inhibitor, venetoclax, with a [...]