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1.
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Genetic aberrations that cause constitutive activation of the receptor tyrosine kinase (RTK), ROS1, can drive cancer formation. Treatment of these cancers with tyrosine k [...]
2022 |
Dissertation |
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2.
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The grim prognosis for pancreatic ductal adenocarcinoma (PDAC) patients impels an improved understanding of disease biology to facilitate the development of enhanced ther [...]
2022 |
Thesis |
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3.
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In this work, I explored epigenetic dysregulation AML by Chromatin dynamics in acute myeloid leukemia subsets defined by genetic and drug response diversity and the ident [...]
2022 |
Dissertation |
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4.
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Acute Myeloid Leukemia (AML) is a genetically and phenotypically heterogeneous white blood cell cancer with a poor prognosis and limited therapeutic options. For many dec [...]
2022 |
Dissertation |
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5.
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Our lab recently identified radiation responsive microRNAs (miRNA) in colorectal cancer (CRC). The most upregulated candidate, miRNA 451a, inhibited tumor cell proliferat [...]
2022 |
Dissertation |
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6.
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Tendons are an essential tissue that join together and transmit force between muscle and bone. While much is known about muscle and skeletal growth mechanisms, remarkably [...]
2021 |
Dissertation |
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7.
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Uveal melanoma (UM) is a rare but aggressive disease, with >50% of tumors propagating metastatic disease spread - associated with nearly uniform fatality. Despite sign [...]
2021 |
Abstract |
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8.
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Women diagnosed with breast cancer within 10 years of a completed pregnancy are 2~3x more likely to develop liver metastases than never-pregnant (nulliparous) patients, e [...]
2021 |
Dissertation |
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9.
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This cancer cell-intrinsic GOT2-PPARĪ“ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment, and fosters the immune-suppressive [...]
2021 |
Dissertation |
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10.
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PIN1 is a phosphorylation-directed member of the peptidyl-prolyl cis/trans isomerase family that facilitates conformational changes in phosphorylated targets such as c-MY [...]
2020 |
Abstract |
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