Department of Physiology and Pharmacology

Angiotensin converting enzyme 2 (ACE2) is a key regulator of the renin angiotensin system (RAS) that acts by degrading angiotensin II (AngII). Within the kidney, ACE2 is [...]

Malaria is a mosquito-borne parasitic disease that has deeply impacted the human population throughout recorded history. The disease burden of malaria has gradually decli [...]

Sympathetic nerves are lost in the damaged myocardium (infarct) after myocardial infarction (MI), and the relative area of denervation predicts risk of sudden cardiac arr [...]

Obesity increases both the incidence and severity of asthma, but the underlying mechanisms leading to the development of obesity-related asthma remain elusive. High insul [...]

My thesis work has focused on the study of a previously undescribed subpopulation of ipRGCs. These cells form an evenly-spaced mosaic and are restricted to the dorsal ret [...]

This dissertation describes the development of the TRADE system for directed evolution of the AAV capsid, its successful application to identify the HN1 variant, a novel [...]

The assays developed in this thesis research also offer a path to address some remaining gaps in our knowledge such as substrate assisted gate closure and the substrate r [...]

The medial olivocochlear (MOC) system aids in the prevention of age- and noise-induced hearing loss, and enhances the detection of salient sound in diverse sensory enviro [...]

Preponderant genomic sequencing and clinical evidence have revealed the remarkable heterogeneity that underpins leukemia. Such efforts have brought to the forefront new o [...]

Amyotrophic Lateral Sclerosis is the most common adult onset motor neurodegenerative disease. The etiology of the disease remains obscure, and as such there is no effecti [...]