Cachexia, characterized by muscle loss, reduced food intake, and decreased activity, is a common complication of chronic diseases such as cancer, renal failure, heart fai [...]

Disease is an ever-present threat to the survival of the individual. To meet these challenges, higher organisms have developed complex mechanisms designed to heal and fig [...]

Chronic stress–driven sympathetic signaling influences cancer development by reshaping the tumor microenvironment (TME). This dissertation reviews how sympathetic nerves [...]

Along with an increasing prevalence of adult obesity worldwide, an increasing prevalence of obesity and its co-morbidities has also been documented in children. Seminal w [...]

Acute Myelogenous Leukemia (AML) is an aggressive cancer of the bone marrow that affects both adults and children alike. While many patients achieve remission following i [...]

Cachexia is a devastating syndrome with cardinal features of anorexia, weight loss, and fatigue. This syndrome occurs during numerous chronic diseases, such as cancer, ci [...]

Cancer cachexia is a co-morbidity highly prevalent in pancreatic ductal adenocarcinoma (PDAC) patients and results in a decreased quality of life.This work expands on pri [...]

Illness behaviors, metabolic disturbances, and cognitive injury are common in cancer patients and frequently lead to wasting or cachexia. This devastating state of malnut [...]

Asthma is characterized by airway hyperreactivity, an abnormal tendency for airways to constrict. Maternal asthma increases the risk of childhood asthma more than paterna [...]