Obese asthmatic patients often have severe symptoms and poor responses to treatment. The molecular mechanisms of obesity-related asthma and associated airway hyperreactiv [...]

Ozone is an environmental component of air pollution. It is a reactive oxygen species that acutely damages airway epithelium, increasing inflammatory cytokines, and neu [...]

Asthma is characterized by airway hyperreactivity, an abnormal tendency for airways to constrict. Maternal asthma increases the risk of childhood asthma more than paterna [...]

This work identifies a novel inhibitory role for muscarinic receptors on human and guinea pig eosinophils and demonstrates their functional importance in vivo. Muscarinic [...]

Parasympathetic nerves strongly regulate airway tone, and in allergic asthma, excess acetylcholine release contributes to airway hyperresponsiveness linked to nerve‑assoc [...]