This dissertation investigates why remyelination becomes inefficient with age in multiple sclerosis (MS) and how this failure drives neuronal loss. Key findings include a [...]

Astrocytes are a type of central nervous system glia that have critical roles within the brain, including supporting synapse formation, synaptic transmission, and maintai [...]

Mitochondria are essential organelles for all cell types, especially for neurons, which possess extremely long axons that require the support of mitochondria from cell bo [...]

Axons can represent the majority of a neuron's volume and are energetically demanding. Specialized glia ensheathe axons to insulate them and are believed to support axon [...]

How injury or neurodegenerative disease alter neural circuit function remains unclear. In this thesis, I explored how axotomy affects severed axons and adjacent uninjured [...]

During animal development, nervous systems over-wire and then refine to shape precise neuronal circuitry. This developmental neuronal remodeling, observed across evolutio [...]

This dissertation characterizes the developmental remodeling of a subset of neurons in the Drosophila nervous system. We highlight how these neurons undergo remodeling of [...]

Exchange of cerebrospinal fluid (CSF) with interstitial fluid (ISF) is a recently elaborated pathway by which solutes are trafficked into and out of the brain. This pathw [...]